The protagonist, William Redmoor, wakes up in a medical ward with amnesia. In addition, the player is also equipped with a notebook in which they can jot down clues with the stylus. It also displays the health bar and can show a map or the player's inventory. The console's touch screen is used to move the character's vision, to change weapons and to interact with some nearby elements. As the game progresses, he finds more weapons, such as a revolver. At the beginning, William only has access to a nightstick that he can use to defend himself against enemies in addition to a flashlight.

In order to advance in the game, the player has to resolve puzzles and defeat monsters. In Dementium: The Ward, the player takes the role of William Redmoor, a man with amnesia, and has to venture through a hospital's rooms and hallways in order to find the exit and escape the establishment. The remastered version was released in North America on Decemand Europe on February 11, 2016. After Renegade Kid gained back the rights to the title, an enhanced version of the game was announced under the title of Dementium Remastered for the Nintendo 3DS. The game was released in North America on October 31, 2007, published by Gamecock Media Group. Dementium: The Ward is a survival horror first-person shooter game developed by Renegade Kid for the Nintendo DS.

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